Treatment of Depressed Chronic Obstructive Pulmonary Disease Patients

Weill Cornell Medicine (WCM) logo

Weill Cornell Medicine (WCM)

Status

Completed

Conditions

Major Depression
Pulmonary Disease, Chronic Obstructive

Treatments

Behavioral: Enhanced Care
Behavioral: Treatment Adherence Intervention

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT00151372
R01HL071992-05 (U.S. NIH Grant/Contract)
0201005319

Details and patient eligibility

About

Approximately 20% of patients with chronic obstructive pulmonary disease (COPD) have major depression, a condition that contributes to suffering but also to poor treatment adherence leading to increased disability and morbidity. This study investigates the effectiveness of a care management intervention aimed at facilitating adherence to a treatment algorithm based on the Agency for Health Care Policy and Research (AHCPR) guidelines. The investigators hypothesize that this intervention, in comparison to usual care, will increase the prescription of adequate antidepressant treatment by physicians, enhance treatment adherence by patients, and reduce depressive symptoms, suicide ideation, and disability at a 28-week follow-up period.

Enrollment

141 patients

Sex

All

Ages

50 to 95 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Chronic obstructive pulmonary disease by American Thoracic Society criteria
  • Major depression by DSM-IV criteria
  • 17-item Hamilton score >14
  • English speaking

Exclusion criteria

  • Inability to give informed consent
  • MiniMental score <24
  • Aphasia
  • Nursing home placement after discharge

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

141 participants in 2 patient groups

Treatment Adherence Intervention
Experimental group
Description:
In the Treatment Adherence Intervention group, a study therapist regularly meets with subjects in order to identify obstacles to depression and chronic obstructive pulmonary disease treatment adherence and to help the participant overcome those obstacles.
Treatment:
Behavioral: Treatment Adherence Intervention
Enhanced Care
Active Comparator group
Description:
In the Enhanced Care group, physicians providing aftercare will be informed in writing of the patients' diagnosis but will receive no clinical instructions by the research team.
Treatment:
Behavioral: Enhanced Care

Trial contacts and locations

3

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Data sourced from clinicaltrials.gov

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