Treatment of Early Nasal Polyposis With Topical Triamcinolone

Steward St. Elizabeth's Medical Center of Boston, Inc.

Status and phase: Terminated; Phase 2; Phase 1

Conditions: Nasal Polyps

Treatments: Drug: Saline soaked sponge; Drug: Triamcinolone

Study type: Interventional

Funder types: Other

Identifiers

NCT01222871

00540

Details and patient eligibility

About

The purpose of this study is to compare the effectiveness of intranasal Triamcinolone delivered through a bio-absorbable nasal dressing verses oral steroids and a saline soaked dressing, in the treatment and prevention of early nasal polyposis.

Full description

nasopore, a bio-absorbable nasal dressing, may offer an alternative route of sustained steroid drug delivery. The use of topical targeted intranasal steroids may prevent the routine adverse effects of oral steroids while maintaining the same therapeutic / clinical efficacy.

Enrollment: 1 patient

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Patients with early nasal polyposis

Exclusion criteria

• Age < 18 years
• Patients with active sinus infections
• Patients on long term steroids
• Allergy or sensitivity to steroids
• Patients with Antrochoanal polyps
• Patients who received topical steroids by bio-resorbable sponge or oral steroids

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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1 participants in 2 patient groups, including a placebo group

Triamcinolone

Experimental group

Description:

Triamcinolone soaked nasopore dressing

Treatment:

Drug: Triamcinolone

Control Group

Placebo Comparator group

Description:

Saline soaked sponge

Treatment:

Drug: Saline soaked sponge