Treatment of Gingival Recession Using Mesenchymal Stem Cells

Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus

Status and phase: Completed; Phase 2; Phase 1

Conditions: Gingival Recession

Treatments: Other: standard treatment; Biological: mesenchymal stem cells

Study type: Interventional

Funder types: Other

Identifiers

NCT04434794

IBCE_MSC(GR2)

Details and patient eligibility

About

Treatment of patients with gingival recession by injection of autologous adipose-derived mesenchymal stem cells mixed with collagen gel

Full description

Treatment of patients with gingival recession by injection of autologous adipose-derived mesenchymal stem cells mixed with collagen gel (1×106cells/0.2 ml). The volume of the mixture is divided into 4 equal injections in the gingival region of one tooth (one place injection volume is 0.05 ml of mixture).

Enrollment: 27 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

-gingival recession

Exclusion criteria

• pregnancy
• breast-feeding
• acute and chronic infectious diseases: HIV, viral hepatitis, tuberculosis
• mental disorders

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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27 participants in 2 patient groups

mesenchymal stem cells

Experimental group

Description:

standard treatment according to clinical protocols plus mesenchymal stem cells

Treatment:

Other: standard treatment

Biological: mesenchymal stem cells

control

Active Comparator group

Description:

standard treatment according to clinical protocols

Treatment:

Other: standard treatment