Treatment of Grammatical Time Marking in Post-Stroke Aphasia

University of Neuchatel

Status: Completed

Conditions: Stroke; Aphasia; Brain Injury, Vascular

Treatments: Behavioral: Speech and language therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05656638

Unine2022-01807

Details and patient eligibility

About

The study aims to assess an individual or self-administered computer therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs treated on the sessions. We also explore whether the observed progress can be transferred to untrained items, more ecological contexts and if is maintained two and four weeks after the end of treatment.

This therapy will be administered to six individuals with brain lesions after stroke. Four individuals will take part of the individual therapy and two individuals will take part of the self-administered computer therapy. The therapy will last one month, at the rate of three weekly sessions of approximately one hour.

Enrollment: 6 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Have had an imaging-objectified stroke in adulthood that resulted in aphasia (fluent or non-fluent). The time between the stroke and participation in this study must be greater than 6 months.
• Be a native French speaker or have excellent mastery of French.
• Be between 18 and 75 years old.
• Present grammatical tense marking disorders objectified by language evaluation (deficit scores on the "Batterie d'Évaluation de la Production Syntaxique" (BEPS) verb flexion task, Monetta et al., 2018; and/or on the "Test d'expression morpho-syntaxique fine" (T.E.M.F.) active sentence production subtask, Bernaert-Paul and Simonin, 2011).

Exclusion criteria

• Present chronic symptoms of a substance use disorder as defined by Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criteria.
• Have significant uncorrected vision and/or hearing impairment.
• Have significant impairments in oral/written comprehension.
• Present apraxia of speech or a severe arthritic disorder
• Present hemineglect
• Present impaired judgment and discernment, objectified by a neuropsychological evaluation

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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6 participants in 1 patient group

Brain-injured participants

Experimental group

Description:

Participants with post-stroke fluent or non-fluent chronic aphasia

Treatment:

Behavioral: Speech and language therapy