Treatment of Hepatocellular Carcinoma With Radiofrequency Ablation (RFA) Associated With Postoperative TACE

Army Medical University

Status: Unknown

Conditions: Cancer of Liver

Treatments: Procedure: radiofrequency ablation only; Procedure: radiofrequency ablation associated with TACE

Study type: Interventional

Funder types: Other

Identifiers

NCT00730860

SWHB002

Details and patient eligibility

About

A RCT was conducted to elucidate whether the treatment outcome of HCC could be improved by RFA associated with postoperative TACE.

Full description

A randomized study was conducted to elucidate whether the outcome of hepatocellular carcinoma could be improved by radiofrequency ablation associated with postoperative transhepatic arterial chemoembolization.

Enrollment: 140 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with hepatocellular,confirmed by pathological examination
• patients with a live function test showed Child A or B
• Indocyanine green test showed less than 30％ after 15min,and the patients showed a tolerance of RFA and TACE
• Tumor stage is early period(according to Milan Standard),that is,the diameter of single node should be less than 5cm；the node of tumor should be less than 3 and the diameter less than 3cm.
• without metastasis in lymphnode or other organs
• written consent inform assigned

Exclusion criteria

• preoperative examination showed malignant thrombosis in the first class branch of portal vein or hepatic vein or vena cava
• metastatic cancer of liver
• patients with a poor tolerance of RFA and TACE
• patients received other therapies.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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140 participants in 2 patient groups

RFA+TACE

Experimental group

Description:

treatment of hepatocellular carcinoma by radiofrequency ablation associated with postoperative transhepatic arterial chemoembolization

Treatment:

Procedure: radiofrequency ablation associated with TACE

RFA only

Active Comparator group

Description:

treatment of hepatocellular carcinoma by radiofrequency ablation only

Treatment:

Procedure: radiofrequency ablation only