Treatment of Human Cord Blood Mononuclear Cell for Delayed Encephalopathy After Carbon Monoxide Poisoning

Liaocheng People's Hospital

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Delayed Encephalopathy After Carbon Monoxide Poisoning

Treatments: Other: hyperbaric oxygen; Biological: Human cord blood mononuclear cell

Study type: Interventional

Funder types: Other

Identifiers

NCT02952716

cell therapy for neurology

Details and patient eligibility

About

The effects and safety of Human cord blood mononuclear cell for delayed encephalopathy after carbon monoxide poisoning

Full description

To evaluate the effect and mechanism of human cord blood mononuclear cell transplantation for delayed encephalopathy after carbon monoxide poisoning

Enrollment: 60 estimated patients

Sex: All

Ages: 35 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 35-60 years old.
• No serious infection, chronic diseases, diabetes and tuberculosis.
• Written informed consents were obtained from all subjects.
• Symptomatic Delayed Encephalopathy After Carbon Monoxide Poisoning.

Exclusion criteria

• The heart, liver, kidney and other viscera serious organic disease.
• Allergic constitution, clotting disorders, autoimmune diseases and tumors.
• Pregnancy.
• Moribund patient.
• History of prior brain injury.
• History of central nervous system disease.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups, including a placebo group

intervention group

Experimental group

Description:

Human Cord Blood Mononuclear Cell will be slowly infusion three times,at one days, 30 days,at 60days.

Treatment:

Other: hyperbaric oxygen

Biological: Human cord blood mononuclear cell

control group

Placebo Comparator group

Description:

hyperbaric oxygen

Treatment:

Other: hyperbaric oxygen