Treatment of Hypertension

National Institutes of Health (NIH)

Status and phase: Completed; Phase 3

Conditions: Hypertension; Cardiovascular Diseases; Vascular Diseases; Heart Diseases

Treatments: Drug: Rauwolfia alkaloids; Drug: chlorothiazide

Study type: Interventional

Funder types: NIH

Identifiers

NCT00000484

3

Details and patient eligibility

About

To determine whether the long-term treatment of essential hypertension without significant target organ disease materially influenced mortality and/or cardiovascular renal morbidity.

Full description

BACKGROUND:

This grant-supported, cooperative, fixed-protocol clinical study was initiated in 1966 and followed a cooperative study of the treatment of renal hypertension initiated in 1960 to evaluate the relative efficacy of several recognized drug regimens for reduction of blood pressure. Six centers (USPHS hospitals) and a coordinating center were involved in the trial.

DESIGN NARRATIVE:

Randomized, double-blind, fixed sample. Three hundred and eighty nine eligible patients were assigned to drug therapy consisting of chlorothiazide plus Rauwolfia serpentina or to placebo.

The study completion date listed in this record was inferred from last publication listed in the Citations section of this study record.

Sex: All

Ages: 21 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Men and women, ages 21-55. Mild essential hypertension (diastolic blood pressure over 90 mm Hg.