Treatment of Hypertension

National Institutes of Health (NIH) logo

National Institutes of Health (NIH)

Status and phase

Completed
Phase 3

Conditions

Hypertension
Cardiovascular Diseases
Vascular Diseases
Heart Diseases

Treatments

Drug: chlorothiazide
Drug: Rauwolfia alkaloids

Study type

Interventional

Funder types

NIH

Identifiers

NCT00000484
3

Details and patient eligibility

About

To determine whether the long-term treatment of essential hypertension without significant target organ disease materially influenced mortality and/or cardiovascular renal morbidity.

Full description

BACKGROUND: This grant-supported, cooperative, fixed-protocol clinical study was initiated in 1966 and followed a cooperative study of the treatment of renal hypertension initiated in 1960 to evaluate the relative efficacy of several recognized drug regimens for reduction of blood pressure. Six centers (USPHS hospitals) and a coordinating center were involved in the trial. DESIGN NARRATIVE: Randomized, double-blind, fixed sample. Three hundred and eighty nine eligible patients were assigned to drug therapy consisting of chlorothiazide plus Rauwolfia serpentina or to placebo. The study completion date listed in this record was inferred from last publication listed in the Citations section of this study record.

Sex

All

Ages

21 to 55 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Men and women, ages 21-55. Mild essential hypertension (diastolic blood pressure over 90 mm Hg.

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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