Treatment of Intrabony Defect in Patient With Periodontitis Stage III by Using I-PRF and Xenograft

Al-Azhar University

Status: Active, not recruiting

Conditions: Intrabony Defects in Chronic Periodontitis; Intrabony Defect

Treatments: Procedure: injectable platelet rich fibrin and xenograft; Procedure: Xenograft alone

Study type: Interventional

Funder types: Other

Identifiers

NCT07261878

P-ME-24-05

Details and patient eligibility

About

Evaluate of the injectable platelet rich fibrin (I-PRF) with xenograft in Intrabony defects of Periodontitis patient stage III versus Xenograft alone.

Full description

All surgical procedures will be conducted by a single operator. Following administration of local anesthesia, intrasulcular incisions will beperformed buccally and lingually/palatally on the affected tooth and extended one adjacent tooth mesially and distally, using 15c blades. Following mucoperiosteal flap elevation, thorough debridement will be performed using ultrasonic scalers and curettes until defects are clear from any granulation tissue, and the defect morphology will be visually explored and recorded. In the group1: xenograft alone(Bovin xenograft)will be applied to the intrabony defect area. In the group 2: xenograft (Bovin xenograft) with injectable platelet Rich fibrin (I- PRF) will be applied to the intrabony defect area. Preperation of Injectable platelate Rich Fibrin (I-PRF) : will be prepared for each patient as follows: 5 ml of venous blood will be collected from the patient blood then placed in a plastic tube without any added material or coagulant and centrifuged at 700 rpm for 3 min. then mixed with Xenograft. Finally, the flap will be passively repositioned using interrupted 4-0 silk

Enrollment: 20 estimated patients

Sex: All

Ages: 30 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patient should have localized Periodontitis stage III grade B with pocket depth ≥ 6mm; indicated for periodontal surgery
2. Patient's agreement to the surgical procedure and clinical trial.
3. Age ranged between 30-55 years old.
4. Intrabony defects with depth ≥3mm.
5. Free from any systemic conditions and no previous drug affect bone metabolism

Exclusion criteria

1. Smoking.
2. Pregnant women.
3. Patients in variation in anatomical landmarks.
4. Patients with psychological problems.
5. Patients with abnormal habits.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

injectable platelet rich fibrin and xenograft

Other group

Description:

Intrasulcular incisions will be performed buccally and lingually/palatally on the affected tooth and extended one adjacent tooth mesially and distally, using 15c blades. Following mucoperiosteal flap elevation, thorough debridement will be performed using ultrasonic scalers and curettes until defects are clear from any granulation tissue, and the defect morphology will be visually explored and recorded .In the group 2: xenograft (Bovin xenograft) with injectable platelet Rich fibrin (I- PRF) will be applied to the intrabony defect area.

Treatment:

Procedure: Xenograft alone

Procedure: injectable platelet rich fibrin and xenograft

xenograft alone

Active Comparator group

Description:

Intrasulcular incisions will be performed buccally and lingually/palatally on the affected tooth and extended one adjacent tooth mesially and distally, using 15c blades. Following mucoperiosteal flap elevation, thorough debridement will be performed using ultrasonic scalers and curettes until defects are clear from any granulation tissue, and the defect morphology will be visually explored and recorded, inserting the xenograft to the defect

Treatment:

Procedure: Xenograft alone

Procedure: injectable platelet rich fibrin and xenograft