Treatment of Knee Osteoarthritis (KOA) by Injection of Autologous Adipose-derived Vascular Matrix Components (SVF) Into Joint Cavity

Air Force Military Medical University of People's Liberation Army

Status

Enrolling

Conditions

Knee Osteoarthritis

Treatments

Behavioral: Stromal vascular fraction,SVF

Study type

Interventional

Funder types

Other

Identifiers

NCT06109220

KY20232112-X-1

Details and patient eligibility

About

The purpose of this study was to analyze and study the efficacy and safety of autologous adipose-derived vascular matrix components (SVF) in patients with knee osteoarthritis before and after treatment through clinical evaluation, radiation index, and metabolic index comparison between plasma and irrigation solution before and after SVF injection.

Enrollment

30 estimated patients

Sex

All

Ages

20 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

The age range is 20-70 years old
Patients with unilateral or bilateral knee degenerative inflammation (KOA) with Kellgren-lawrence rating of level 3 or lower
The physical health status is mainly in the ASA grade Ⅰ, Ⅱ and Ⅲ
Subjects had no active tumors, no active inflammation, no treponema pallidum, HIV, hepatitis B virus, or hepatitis C virus
The subject shall provide the physical examination report of knee X-ray examination, MRI examination and other items

Exclusion criteria

Patients with nonunion or displaced fractures around defective cartilage
Pregnant or lactating women
Autoimmune disease
Subjects with diabetes (exceptions are patients whose blood sugar levels remain within the normal range and diabetes has not caused other complications)
The patients had severe neurological diseases affecting the evaluation of postoperative results