Treatment of Localized Low Grade Lymphomas

French Innovative Leukemia Organisation

Status and phase: Completed; Phase 3

Conditions: Lymphoma, Low-Grade

Treatments: Procedure: radiotherapy; Drug: MINI CHEP

Study type: Interventional

Funder types: Other

Identifiers

NCT00536458

GOELAMS 01 02

GOELNH LOGLOC

01 02

Details and patient eligibility

About

To compare localiezd radiotherapy to localized radiotherapy followed by 6 cycles of chemotherapy in the treatment of localiezd low grade lymphoma

Full description

The standard treatment ol localized low grade lymphomas is Radiotherapy alone can offer long term remissions to some patients .

No study have clearly demonstrated the interest of chemotherapy. The purpose of the study is to determine wether prednisone administrated after first line local radiotherapy (30 GY) can pre in the treatment of localized low grade lymphomas of adult patients

Enrollment: 132 patients

Sex: All

Ages: 18 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Low grade lymphoma defined according to the Ann Arbor classification
• localized

Exclusion criteria

• Subjects unable to signed informed consent
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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132 participants in 2 patient groups

radiotherapy

Experimental group

Description:

minichep + radiotherapy

Treatment:

Procedure: radiotherapy

B

Active Comparator group

Description:

MINI CHEP

Treatment:

Drug: MINI CHEP