Treatment of Melasma Using Q-switched Nd: YAG Laser and Fractional CO2 Laser Separately and in Combination

Kasr El Aini Hospital

Status: Completed

Conditions: Melasma

Treatments: Device: Q switched Nd YAG laser; Device: Fractional CO2 laser

Study type: Interventional

Funder types: Other

Identifiers

NCT03848013

CairoU

Details and patient eligibility

About

• All participants will be divided into 2 groups : Group A & Group B.
• Group A will be subjected to 3 consecutive sessions of Q-switched 1,064 nm Nd: YAG laser to one side of the face & fractional co2 laser to the other side of the face with one month interval between sessions.
• Group B will be subjected also to 3 consecutive sessions of Q-switched 1,064 nm Nd: YAG laser to one side of the face & an additional fractional co2 laser to the other side of the face using the above mentioned parameters with one month interval between sessions.
• Response to treatment will be assessed using the Melanin Index (MI) score, Melasma Area and Severity Index (MASI) score, spectrophotometer ( Derma catch, colorix, Neuchatel, Switzerland ) and a subjective self-assessment method.

Enrollment: 30 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• melasma patients above 18 years

Exclusion criteria

• Pregnancy.
• Usage of chemical peeling 1 month prior to the study.
• Isotretinoin intake 6 months prior to the study.
• Any laser procedure related to melasma lesions 1 month prior to the study.
• Active herpetic lesions.
• Any concurrent active skin disease within the treated area.
• Photosensitive skin conditions such as systemic lupus erythematous.
• History of delayed wound healing.
• Keloid formation.
• Bleeding diathesis.
• Medical conditions such as diabetes mellitus & autoimmune diseases.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

Treatment

Active Comparator group

Description:

Treatment of cases of melasma using Q switched Nd YAG laser and Fractional CO2 laser separately and in combination

Treatment:

Device: Q switched Nd YAG laser

Device: Fractional CO2 laser

Follow -up period

No Intervention group

Description:

follow up of the treated cases for 2 months