Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid

Emory University

Status and phase: Completed; Phase 4

Conditions: Melasma

Treatments: Procedure: Jessner's solution chemical peel; Procedure: Trichloroacetic acid chemical peel

Study type: Interventional

Funder types: Other

Identifiers

NCT00166192

IRB00024850

Details and patient eligibility

About

Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical peel involves applying the peeling agent to the skin for a short period. The skin will peel similar to a sunburn, and moisturizers are applied to the skin. Although both agents are well-accepted, there have been no good comparisons of the two agents. The purpose of this study is determine if there is a difference in the effectiveness of these two agents.

Enrollment: 19 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults > 18 years old
• Clinical diagnosis of melasma
• Mental capacity to give informed consent

Exclusion criteria

• Pregnancy
• H/o allergy to Jessner's solution, tricholoracetetic acid, tretinoin, or hydroquinone
• Active dermatitis
• Presence of cutaneous infection

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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19 participants in 1 patient group

Chemical Peel

Active Comparator group

Description:

Split face treatment paradigm

Treatment:

Procedure: Jessner's solution chemical peel

Procedure: Trichloroacetic acid chemical peel