Treatment of Mild and Subthreshold Depressive Disorders

Ludwig Maximilian University of Munich

Status and phase: Unknown; Phase 4

Conditions: Depression

Treatments: Behavioral: Non-specific supporting group therapy; Drug: Sertralin; Behavioral: Cognitive-behavioral therapy; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT00226642

KNDS-2.1

Details and patient eligibility

About

The purpose of this study is to determine the efficacy of a SSRI, cognitive-bahavioral-therapy and a free choice between SSRI and CBT in a sample of primary care patients suffering from mild to moderate depression.

Hypotheses:

• SSRI is superior to placebo
• CBT is superior to a non-specific supporting group therapy

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:(e.g.)

• subthreshold and mild depressive disorders including dysthymia (HAMD: 8-22)
• informed consent
• 18 years

Exclusion Criteria:(e.g.)

• severe mood disorders
• bipolar disorder
• recurrent brief depression
• suicidality
• alcohol or drug dependency
• obsessive-compulsive disorder
• schizoaffective disorder / schizophrenia
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind