Treatment of Mild to Moderate Joint Pain in Patients With Chronic Plaque Psoriasis Receiving Efalizumab

Probity Medical Research

Status and phase

Completed

Phase 4

Conditions

Arthritis

Arthralgia

Treatments

Drug: Acetaminophen

Drug: NSAID

Study type

Interventional

Funder types

NETWORK

Identifiers

NCT00510536

P07-104

Details and patient eligibility

About

The purpose of this study is to evaluate tolerability and effectiveness of conventional treatment for mild to moderate arthritic or arthralgic symptoms while subjects are being treated with efalizumab for psoriasis.

Full description

The study objective is to demonstrate that mild to moderate arthritis or arthralgia may be controlled using conventional therapy while being treated with efalizumab, without loss of efficacy.

Enrollment

50 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Females cannot become pregnant while participating in study.
Have a history of plaque psoriasis for at least 6 months.
Receiving or about to receive efalizumab for the treatment of chronic plaque psoriasis.
Have mild to moderate arthritis or arthralgia occurring while on treatment with efalizumab or untreated mild to moderate arthritis or arthralgia present at the time of initiating treatment with efalizumab.

Exclusion criteria

Previous systemic treatment with biologics other than efalizumab, within 3 months.
Treatment with any systemic corticosteroids or intra-articular corticosteroid injection, cyclosporine or methotrexate within 28 days.
Any previous treatment with chlorambucil or cyclophosphamide.
Have active tuberculosis or are currently receiving treatment or prophylactic therapy for tuberculosis.
Have other serious disorders; such as, congestive heart failure, prior or current history of blood dyscrasia, or central nervous system demyelinating disorders.
Has a sensitivity, intolerance, or history of gastrointestinal bleeding associated with diclofenac, indomethacin, and/or ibuprofen.