Treatment of Multiple Gingival Recession Defects Using a New Xenogenic Collagen Membrane Compared to Connective Tissue Graft: a Randomized Controlled Split-mouth Clinical Study (Mucogreffe)

Centre Hospitalier Universitaire de Nice

Status: Enrolling

Conditions: Gingival Recession

Treatments: Procedure: Treatment of gingival recessions

Study type: Interventional

Funder types: Other

Identifiers

NCT04800250

20-PP-26

Details and patient eligibility

About

Limitation of donor site and significant postoperative morbidity are often described in connective tissue graft. We want to show if mucogain matrix used in tunnel technique to recover RTI Cairo recessions defects could be an alternative to connective tissue graft

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with 3 contiguous, symmetrical and bilateral RTI Cairo gingival recessions (Miller Class 1) (i.e. 6 recessions)
• Patient non-smoker
• Patient affiliated to social security
• Patient signed informed consent.

Exclusion criteria

• Patient with or having presented an acute or chronic severe cardiovascular, kidney, liver, gastrointestinal, allergic, endocrine, neuropsychiatric pathology, developed cancer of the upper aero digestive tract treated with radiotherapy
• Patient with severe hemorrhinopathy
• Patient treated with oral retinoids, bisphosphonates, oral or anticonvulsants
• Patient who has taken steroidal or non-steroidal anti-inflammatory therapy, anti-cancer or immunosuppressive chemotherapy within the last 6 months.
• Patient with contraindication to necessary and pre-, per- or post-operative treatments
• Follow-up of the patient seemed difficult by the investigator
• Patient with insufficient oral hygiene incompatible with oral surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

A - Mucogain matrix on right

Experimental group

Description:

The patient will receive mucogain matrix on right side and connective tissue graft on left side.

Treatment:

Procedure: Treatment of gingival recessions

B - Mucogain matrix on left

Experimental group

Description:

The patient will receive mucogain matrix on left side and connective tissue graft on right side.

Treatment:

Procedure: Treatment of gingival recessions