Status and phase
Conditions
Treatments
About
Donor mobilization :
Donor will be mobilized with G-CSF (Granocyte) sub-cutaneous 10 µg/kg/day during 5 to 6 days.
Hematopoïetic Stem Cell Harvest:
By 1, 2, or 3 aphaeresis, a number of 4 x 106 cellules CD34+ /kg is required. If the CD34+ >= 2 and <= 4x106/kg: the center must decide on the strategy Decision. In case of insufficient graft : a Bone Marrow Harvest is recommended Conditioning : Fludarabine - Busulfan - ATG
Transplant : HSC at D0
• 3 months after Transplantation :
Disease Evaluation :
If CR : Supervision. Then if progression: 4 cycles of Bortezomib.
If no CR : Bortezomib (4 cycles)
• Evaluation after Bortezomib cycles
If CR : Supervision. Then, if progression and no GvHD : DLI If no RC and no GVHD : DLI
Enrollment
Sex
Ages
Volunteers
Inclusion and exclusion criteria
Inclusion Criteria:
AND
Primary purpose
Allocation
Interventional model
Masking
13 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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