Status and phase
Conditions
Treatments
About
The trial proposed here attempts to reduce induction chemotherapy to phase I of standard induction in patients with B-precursor ALL. Induction phase II will be replaced by blinatumomab.
The initial treatment phase is followed by sequential chemotherapy and further blinatumomab cycles.
Full description
Blinatumomab is a bispecific single-chain antibody construct designed to link B cells and T cells resulting in T-cell activation and a cytotoxic T-cell response against CD19 expressing cells. In Phase II-III clinical trials 43-69 % of the patients treated with blinatumomab in relapsed/refractory ALL with poor prognostic features, achieved a complete hematologic remission and around 80 % of these obtained a molecular remission as well. Blinatumomab thus has demonstrated significant antileukemic activity in relapsed/refractory adult ALL. The ultimate goal for optimised management of adult ALL is to integrate targeted compounds with known single-drug activity into first-line treatment.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Patients with newly diagnosed CD19 positive B-precursor ALL
Greater than 25 % blasts in bone marrow
Eastern Cooperative Oncology Group (ECOG) performance status <= 2
Charlson comorbidity score <= 2
Age > 55 and < 75 years at the time of informed consent
Renal and hepatic function as defined below:
Negative pregnancy test in women of childbearing potential
Ability to understand and willingness to sign a written informed consent
For Germany: Participation in the registry of the German Multicenter Study Group for Adult ALL (GMALL)
Exclusion criteria
Antileukemic pretreatment (GMALL prephase with dexamethasone and cyclophosphamide allowed)
History of malignancy other than ALL within 5 years prior to start of protocol-specified therapy with the exception of:
History or presence of clinically relevant (per investigator's assessment) CNS pathology such as epilepsy, childhood or adult seizure, paresis, aphasia, stroke, severe brain injuries, dementia, Parkinson's disease, cerebellar disease, organic brain syndrome or psychosis
Active ALL in the CNS confirmed by CSF analysis) or testes (clinical diagnosis) or other extramedullary involvement; non-bulky lymph node (< 7.5 cm diameter) involvement will be accepted
Current autoimmune disease or history of autoimmune disease with potential CNS involvement
Known exclusion criteria to recommended chemotherapy
Known positivity of HIV, hepatitis B (HbsAG) or hepatitis C virus (anti-HCV)
Subject received prior anti-CD19 therapy
Live vaccination within 2 weeks before the start of study treatment
Known hypersensitivity to immunoglobulins or to any other component of the study drug formulation:
Subject has known sensitivity to immunoglobulins or any of the products or components to be administered during dosing
Currently receiving treatment in another investigational device or drug study or less than 30 days since ending treatment on another investigational device or drug study(s). Thirty days is calculated from day 1 of protocol-specified therapy
Subject likely to not be available to complete all protocol-required study visits or procedures, including follow-up visits, and/or to comply with all required study procedures to the best of the subject's and investigator's knowledge
History or evidence of any other clinically significant disorder, condition or disease (with the exception of those outlined above) that, in the opinion of the investigator would pose a risk to subject safety of interfere with the study evaluation, procedures or completion
Woman of childbearing potential and is not willing to use a highly effective method of contraception while receiving study treatment and for an additional 3 months after the last dose of study treatment
Male who has a female partner of childbearing potential, and is not willing to use 2 highly effective forms of contraception while receiving protocol-specified therapy and for at least an additional 3 months after the last dose of protocol-specified therapy.
Primary purpose
Allocation
Interventional model
Masking
52 participants in 1 patient group
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Central trial contact
Nicola Goekbuget, MD
Data sourced from clinicaltrials.gov
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