Treatment of Paradoxical Vocal Fold Motion Disorder (PVFMD) With a Form of Respiratory Retraining Technique (PVFMDRespRet)

Boston Medical Center (BMC)

Status: Completed

Conditions: Paradoxical Vocal Fold Motion Disorder; Vocal Cord Dysfunction

Treatments: Behavioral: Respiratory retraining for PVFMD

Study type: Interventional

Funder types: Other

Identifiers

NCT02859974

H-33940

Details and patient eligibility

About

Paradoxical Vocal Fold Motion Disorder (PVFMD), otherwise known as vocal cord dysfunction (VCD) is a laryngeal breathing disorder that has several potential causes. In some individuals, exertion is the predominant trigger. PVFMD can present like an asthma attack, but asthma medication is ineffective in treating it. The effects of untreated PVFMD can be devastating, leading to harmful, invasive, and ineffective treatments over a period of years. Numerous anecdotal reports indicate that several behavioral techniques, may be surprisingly effective and even curative. However, data are lacking. The form of respiratory retraining technique tested in the current study educates people with PVFMD about breathing and teaches them a number of breathing exercises specially designed to restore normal breathing patterns.

This case series study will use a dyspnea perception questionnaire, patient daily logs, and physiological measurements of heart rate and breathing to examine whether this form of therapy can improve exertion-induced PVFMD symptoms.

Enrollment: 15 patients

Sex: All

Ages: 12+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Otherwise healthy according to available medical history or by patient and parent report on the health questionnaire
• Patients with no history of asthma, or well-controlled asthma
• A diagnosis of PVFMD by an otolaryngologist based on set criteria in-line with the National Jewish PVFMD diagnostics protocol (based on Hicks, 2008; Hoyte, 2013, Martin, 1987), to be confirmed by an additional otolaryngologist blinded to the initial diagnosis
• A score of three or more on the dyspnea index (DI)

Exclusion criteria

• A score of less than three on the DI
• People diagnosed with hypertension, cardiac disorders or severe pulmonary diseases which affect blood oxygen saturation
• Uncontrolled asthma

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Respiratory retraining for PVFMD

Experimental group

Description:

Single arm study

Treatment:

Behavioral: Respiratory retraining for PVFMD