Treatment of Patients With Active Neurocysticercosis in Eastern Africa (TOPANA)

Technical University of Munich

Status: Completed

Conditions: Neurocysticercosis

Study type: Observational

Funder types: Other

Identifiers

NCT03834337

TOPANA

Details and patient eligibility

About

This multi-centre prospective cohort study of symptomatic patients with active neurocysticercosis (NCC) aims to identify factors related to treatment success of anthelmintic therapy.

Neurological symptom/sign and cyst resolution, quality of life, accuracy and performance of serological T. solium diagnostics and NCC-specific immunological parameter will be followed up at multiple time points in the study. The final assessment will be done six months after the end of anthelmintic treatment. This study aims to guide treatment of NCC in sub-Saharan Africa by identifying factors that are associated with treatment outcomes.

The factors that cause some people to fail complete resolution of all cysts and/or symptoms/signs are unknown.

Enrollment: 63 patients

Sex: All

Ages: 10+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients will be included who
• Meet the definitions of active NCC
• Have epilepsy, epileptic seizures or chronic/severe progressive headaches
• Are physically and mentally fit enough for treatment
• Are willing to be hospitalized and to receive the standard treatment for NCC
• Are willing to participate a follow-up for six months
• Are willing and able to consent to this study, with consent recorded on a signed consent form

Exclusion criteria

• Potential participants who will not meet the above inclusion criteria will be excluded.
• Women who are pregnant will not be included, but re-evaluated for inclusion into the study after they have given birth.
• Potential participants who are currently taking or have taken albendazole, praziquantel, or a corticosteroid within the past 12 months will be excluded.
• People with uncontrolled hypertension and/or diabetes will be excluded from the study but will be re-evaluated for inclusion once their hypertension and/or diabetes have been treated.
• People with chronic consuming illness such as cancer and those with mental handicap severe enough to not allow them to follow the study instructions or reliably take their medication will be excluded.
• Children aged <10 years.