Treatment of PED With AMT and Autologous Serum

King Khaled Eye Specialist Hospital

Status: Completed

Conditions: Corneal Epithelial Defect

Treatments: Procedure: Amniotic membrane transplantation; Drug: Autologous serum/BSS 20%

Study type: Interventional

Funder types: Other

Identifiers

NCT00238862

RP0511-P

Details and patient eligibility

About

Patients with persistent corneal epithelial defects who have not responded to conventional therapy will be randomized to treatment with either amniotic membrane transplantation or autologous serum 20%. Outcome measures will be (1) presence or absence of complete re-epithelialization within 28 days and (2) retention of intact epithelium for at least 90 days.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Corneal epithelial defect of more than 14 days that has not responded to conventional therapy

Exclusion criteria

• Under age 18
• Pregnant/lactating females
• Patients with hemoglobin levels < 12 mg/ml
• Patients with limbal stem cell deficiency

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)