Treatment of Peri-calcification Edema in Neurocysticercosis (NCC)

Universidad Peruana Cayetano Heredia

Status and phase: Terminated; Phase 3; Phase 2

Conditions: Neurocysticercosis

Treatments: Drug: Acetazolamide; Drug: Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT02945527

62352

Details and patient eligibility

About

Three-arm open, randomized comparative study of acetazolamide, dexamethasone, or no additional treatment to evaluate decrease in peri-calcification edema in neurocysticercosis

Full description

This study will evaluate 24 patients with calcified NCC and edema in three treatment arms to compare the reduction in edema volume

Enrollment: 4 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Calcified NCC
• Perilesional edema on CT or MRI
• Normal lab values

Exclusion criteria

• Viable neurocysticercosis
• Status epilepticus
• Symptomatic intracranial hypertension
• Tuberculosis
• More than 7 days after seizure
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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4 participants in 3 patient groups

Acetazolamide

Active Comparator group

Description:

750 mg acetazolamide p.o. divided in three dily doses, for 10 days

Treatment:

Drug: Acetazolamide

Dexamethasone

Active Comparator group

Description:

8 mg p.o. divided in three daily daily doses, for 2 days followed by gradual tapering

Treatment:

Drug: Dexamethasone

No additional anti-edema treatment

No Intervention group

Description:

No additional treatment