Treatment of Periodontal Intrabony Defects With A-PRF or OFD

Semmelweis University

Status: Completed

Conditions: Periodontal Diseases

Treatments: Procedure: A-PRF/OFD

Study type: Interventional

Funder types: Other

Identifiers

NCT04823572

SE TUKEB 254/2017

Details and patient eligibility

About

The aim of this randomized clinical trial was to clinically evaluate and compare the healing of intrabony defects after treatment with advanced platelet-rich fibrin (A-PRF+) toped flap debridement (OFD) in periodontitis patients.

Full description

Thirty (30) intrabony defects are randomly divided in two treatment groups: test (n = 15) and control (n = 15). The intrabony defects are filled with A-PRF+ (n=15) in the test group, respectively treated with open flap debridement in the control group, and fixed with sutures to ensure wound closure and stability.

Enrollment: 30 patients

Sex: All

Ages: 35 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• no systemic diseases
• a good level of oral hygiene
• presence of a 2-, 3-, or combined 2-3-wall intrabony defect with a defect angle of 20-40 (+/- 5) degrees
• with a minimum PPD of 6 mm and intrabony component of a minimum 4 mm as detected on radiographs
• no smoking

Exclusion criteria

• systemic diseases that could influence the outcome of the therapy
• poor oral hygiene
• smoking
• horizontal bone loss

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

A-PRF Advanced Platelet-Rich Fibrin

Active Comparator group

Description:

Comparing healing effect of an autologous product with open flap debridement.

Treatment:

Procedure: A-PRF/OFD

OFD Open Flap Debridement

Active Comparator group

Description:

Comparing healing effect of an autologous product with open flap debridement.

Treatment:

Procedure: A-PRF/OFD