Treatment of Plane Warts With Topical and Oral Retinoids

Tishreen University

Status and phase: Completed; Phase 4

Conditions: Plane Warts

Treatments: Drug: Topical tretinoin 0.05%; Drug: Topical tretinoin 0.05% + oral isotretinoin (0.5 mg/kg/day)

Study type: Interventional

Funder types: Other

Identifiers

NCT07012811

TishreenU - Plane Warts

Details and patient eligibility

About

The aim of this study was to compare the effectiveness and safety of topical tretinoin cream 0.05% alone against combination with oral isotretinoin (0.5 mg/kg/day) for treatment of plane warts.

Full description

This study included 39 patients divided into two groups. Treatment was given for three months duration. Patients were followed-up for further three months to assess the recurrence rate. Combination treatment led to a faster resolution and a higher percentage of complete response. It presents a promising effective alternative option for treatment of plane warts.

Enrollment: 39 patients

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients above 12 years diagnosed with plane warts.
• Patients who had not received any treatment for warts in the last month.

Exclusion criteria

• Pregnancy and lactation.
• Abnormal lipid profile.
• Significant hepatic or renal dysfunction.
• Depression.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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39 participants in 2 patient groups

Group A

Active Comparator group

Description:

Patients apply tretinoin cream 0.05% once daily at night for 3 months

Treatment:

Drug: Topical tretinoin 0.05%

Group B

Experimental group

Description:

Patients apply tretinoin cream 0.05% and receive oral isotretinoin capsule in the dose of 0.5 mg/kg/day for 3 months

Treatment:

Drug: Topical tretinoin 0.05% + oral isotretinoin (0.5 mg/kg/day)