Treatment of Refractory Auditory Verbal Hallucinations With tDCS in Schizophrenia

Seoul National University

Status and phase: Completed; Phase 2; Phase 1

Conditions: Schizophrenia

Treatments: Device: tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT02451371

1501-022-638

Details and patient eligibility

About

The purpose of this study is to exploratively evaluate the efficacy and safety of transcranial direct current stimulation (tDCS) in patients with schizophrenia who experience persistent auditory verbal hallucinations after adequate antipsychotics therapy for over three months.

Enrollment: 10 patients

Sex: All

Ages: 19 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with schizophrenia by the Diagnostic and Statistical Manual of Mental Disorders, Fourth edition, Text Revision (DSM-IV-TR)
• Presence of auditory hallucination after three months' trial of antipsychotics of adequate dose
• The Hamilton Program for Schizophrenia Voices Questionnaire (HPSVQ) score is at least 8

Exclusion criteria

• Significant brain pathology including head trauma, seizure, meningitis
• Intellectual disability (IQ < 70)
• Severe personality disorder
• Substance use disorder (except nicotine)
• Severe medical illness
• Disability in the sensory organs
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

tDCS

Experimental group

Description:

Patients with schizophrenia to receive tDCS treatment

Treatment:

Device: tDCS