Treatment of Tempromandibular Joint Anterior Disc Displacement With Different Materials

Mansoura University

Status: Completed

Conditions: TMJ Disc Disorder

Treatments: Procedure: intra-articular injection with Hyaluronic Acid.; Procedure: intra-articular injection with Platelet lysate (PL).

Study type: Interventional

Funder types: Other

Identifiers

NCT06441279

A0103024OS

Details and patient eligibility

About

comparing the clinical efficacy of intra-articular injection of platelet lysate (PL), versus Hyaluronic Acid after arthrocentesis in the management of patients with anterior disc displacement with reduction.

Enrollment: 60 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients that will be diagnosed with anterior disc displacement with reduction (ADDWR) both clinically and through magnetic resonance imaging scan (MRI).
• Patients who will not respond to a previous conservative therapy.
• Patients with pain in temporomandibular joints.
• Patients with normal or limitation in mouth opening.
• Patients with clicking sound.

Exclusion criteria

• Patients with previous invasive TMJ surgical procedures.
• Patients with inflammatory or connective tissue diseases.
• Patients with neurologic disorders.
• Patients with history of bony or fibrous adhesion.
• Patients having gross mechanical restrictions and condylar fractures.
• Patients with psychological problems.
• Patients receiving anti-coagulation treatment, non-steroidal anti-inflammatory drugs within 48 hours pre-operatively, corticosteroid injection at the treatment site within one month or systemic use of corticosteroids within 2 weeks.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

group 1

Experimental group

Description:

30 patients that will have intra-articular injection of 2 ml of Platelet lysate (PL).

Treatment:

Procedure: intra-articular injection with Platelet lysate (PL).

group 2

Experimental group

Description:

30 patients that will have intra-articular injection of Hyaluronic Acid.

Treatment:

Procedure: intra-articular injection with Hyaluronic Acid.