Treatment Outcomes of Advanced Neoplasia in IBD

Radboud University Medical Center

Status: Active, not recruiting

Conditions: Inflammatory Bowel Diseases

Treatments: Procedure: Endoscopic or surgical resection

Study type: Observational

Funder types: Other

Identifiers

NCT05674773

2017-3219

Details and patient eligibility

About

In this study, we aimed to (1) compare cumulative incidences of synchronous and metachronous colorectal neoplasia as well as mortality following AN in CD and UC patients who underwent proctocolectomy, (sub)total colectomy, partial colectomy or endoscopic resection, and (2) to determine factors associated with AN treatment choice.

Full description

In this retrospective multicenter cohort study, using PALGA (the Dutch nationwide pathology databank), partial colectomy yielded a similar metachronous neoplasia risk compared to (sub)total colectomy after treatment of advanced neoplasia in inflammatory bowel disease. High metachronous neoplasia rates after endoscopic resection underline the importance of strict subsequent endoscopic surveillance.

Enrollment: 189 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• IBD (ulcerative colitis (UC), CD or IBD-unclassified (IBD-U))
• Histological diagnosis of colorectal AN
• Available treatment data

Exclusion criteria

• Familial CRC syndrome
• AN prior to IBD diagnosis

Trial design

189 participants in 1 patient group

IBD patients with advanced neoplasia

Description:

IBD patients with advanced neoplasia (high-grade dysplasia or colorectal cancer) treated with: * proctocolectomy * (sub)total colectomy * partial colectomy * endoscopic resection

Treatment:

Procedure: Endoscopic or surgical resection