Treatment Rates and Compliance to Treatment in Patients With Familial Hypercholesterolemia

Ankara Yildirim Beyazıt University

Status: Completed

Conditions: Familial Hypercholesterolemia

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04494464

Hypercholesterolemia

Details and patient eligibility

About

Familial hypercholesterolemia is a genetic disease characterized by increased levels of low density lipoprotein cholesterol (LDL-C). It is underdiagnosed and undertreated despite relatively high prevalence and significant association with increased mortality.

Full description

Patients older than 18 years old and have a serum low density LDL-C≥250 mg/dL were identified from the hospital database. A questionnaire was completed via phone. Patients were classified as definite, probable and possible familial hypercholesterolemia according to Dutch Lipid Clinical Network Criteria

Enrollment: 367 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients older than 18 years old and have a serum LDL-C≥250 mg/dL

Exclusion criteria

• Patients who refuse dto interview
• Serum TSH≥10 mIU/mL
• Glomerulonephritis or nephrotic syndrome
• ALT or AST higher than 3 times of normal limits
• Serum triglyceride >400 mg/dL

Trial design

367 participants in 1 patient group

Patients with LDL cholesterol ≥250 mg/dL

Description:

Patients older than 18 years old and have a serum LDL-C≥250 mg/dL between January 2010 and December 2016. Patients with a serum TSH≥10 mIU/mL, patients with glomerulonephritis or nephrotic syndrome, patients with ALT or AST higher than 3 times of normal limits and patients with serum triglyceride \>400 mg/dL were excluded.

Treatment:

Other: No intervention