Treatment Resistance Related With Gene Expression Profile of Diffuse Large B-cell Lymphoma

Samsung Medical Center

Status: Completed

Conditions: Diffuse Large B-cell Lymphoma

Study type: Observational

Funder types: Other

Identifiers

NCT01606605

2010-05-025

Details and patient eligibility

About

The investigators perform a retrospective microarray gene expression profiling study of FFPE from a cohort of DLBCL patients with whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay. The investigators also study the pattern of microRNA from patients with diffuse large B-cell lymphoma. The results of gene expression profiles and microRNA is correlated with clinical outcomes of diffuse large B-cell lymphoma.

Full description

1. Whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay

   • Diffuse large B-cell lymphoma patients
   • Paraffin-embedded tissue
   • End points: Progression-free survival, overall survival
   • Statistics: Leave one-out method

2. Nano string assay for microRNA

   • Diffuse large B-cell lymphoma patients
   • Paraffin-embedded tissue
   • End points: Progression-free survival, overall survival
   • Statistics: Leave one-out method

Enrollment: 350 patients

Sex: All

Ages: 15 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed with diffuse large B-cell lymphoma
• Patients with tissue blocks available for study
• Patients with adequate medical records

Exclusion criteria

• Patients diagnosed with other subtypes of lymphoma

Trial design

350 participants in 1 patient group

Diffuse large B-cell lymphoma

Description:

Patients diagnosed and treated at the Samsung Medical Center