Treatment Response of Maintenance Dose of Proton Pump Inhibitor in Patients With Nonerosive Gatroesophageal Reflux Disease

Yonsei University

Status

Completed

Conditions

Non-erosive Gatroesophageal Reflux Disease

Treatments

Drug: PPI

Study type

Interventional

Funder types

Other

Identifiers

NCT03436914

4-2017-1143

Details and patient eligibility

About

For ERD(erosive reflux disease), which pathogenesis is mainly the acid reflux mechanism, primary treatment is therefore PPI. However, NERD(non-erosive reflux disease) is much more complex than ERD and there are more factors causing the typical symptoms. As a result, there is no consensus for the treatment of NERD besides using PPI similar to GERD(gastroesophageal reflux diseas). This study intent to evaluate the effect of PPI(Esomezol) on NERD patients and analyze the improvement of symptoms and the factors related to the result.

Full description

(1) Among GERD patients, EGD(esophagogastroduodenoscopy) must be done before 6 months and must prove there is no erosive lesion. (2) During EGD, esophagus mucosa histology will be taken for evaluation. (3) For NERD patients, Esomezol is given once a day (before breakfast meal), for whole 8 weeks. (4) PAGI-SYM and HAD-K is evaluated and score just before the administration of PPI, 4weeks after and 8weeks after the study initiation.

Enrollment

62 patients

Sex

All

Ages

19 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient over 19 years old
Patient with typical GERD symptom (heartburn or acid reflux more than once a week)

Exclusion criteria

Patient who received EGD since the past 6 months, and diagnosed as GERD endoscopically
Patient with active gastric/duodenal ulcer
Patient who received esophagus, stomach or duodenum surgery
Patient with hypersensitivity to esomezol®
Patient with no achieved agreement on the study from the guardian or patient himself.