Treatment Strategies for Unruptured Intracranial Aneurysms in the Chinese Population China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA)

Capital Medical University

Status: Completed

Conditions: Unruptured Intracranial Aneurysm

Treatments: Other: observation

Study type: Observational

Funder types: Other

Identifiers

NCT05844163

KY2022-226

Details and patient eligibility

About

The goal of this prospective observational cohort study is to learn about treatment strategies for unruptured intracranial aneurysms in the Chinese population. The main questions it aims to answer are:

• To establish a cohort of patients with intracranial unruptured aneurysm and explore the optimal clinical treatment strategy.
• To establish clinical management path for patients with unruptured intracranial aneurysm.

According to the treatment of all patients with unruptured intracranial aneurysm, they were divided into the following groups: 1. Conservative treatment group; 2. Intracranial aneurysm clipping group; 3. Coil embolization or stent-assisted coil embolization group; 4. Flow diversion group.

Enrollment: 31,595 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

A. age > 18 years. B. at least one intracranial aneurysm needs to be treated by craniotomy, endovascular treatment or combined surgery.

C. patients' consent were obtained.

Exclusion criteria

1. Ruptured intracranial aneurysms, accompanied by subarachnoid hemorrhage or cerebral hemorrhage ;
2. Traumatic, infectious and atrial myxoma-associated intracranial aneurysms ;
3. Combined with cerebrovascular malformations;
4. Combined with brain tumors or malignant tumors in other parts ;
5. Combined with systemic connective tissue disease and systemic rheumatic disease ;
6. Due to other diseases, or poor general condition, the expected survival time is not more than 12 months ;
7. During pregnancy and perinatal period.

Trial design

31,595 participants in 3 patient groups

Intracranial aneurysm clipping group

Description:

Patients in Intracranial aneurysm clipping group receive neurosurgical clipping.

Treatment:

Other: observation

Coil embolization or stent-assisted coil embolization group

Description:

Patients in coil embolization or stent-assisted coil embolization group receive coil embolization or stent-assisted coil embolization according to individualized condition.

Treatment:

Other: observation

Flow diversion group.

Description:

Patients in flow diversion group receive flow diverters.

Treatment:

Other: observation