Treatments for Brain Metastases With Poor Prognostic Factors (TBMPPF)

Sun Yat-sen University

Status: Invitation-only

Conditions: Brain Metastases

Treatments: Procedure: neurosurgical resection

Study type: Observational

Funder types: Other

Identifiers

NCT05609162

B2020-218-01

Details and patient eligibility

About

The goal of this observational study is to learn about treatments in brain metastases with poor prognostic factors. The main questions it aims to answer are:

• What kind of local treatment provides a survival benefit for patients with poor prognostic factors?
• What kind of systemic treatment provides a survival benefit for patients with poor prognostic factors?
• Will the combination of local treatment and systemic treatment provide a survival benefit for patients with poor prognostic factors?

Participants will be asked to provide personal information about their living status, symptoms, and disease control during the follow-up.

Enrollment: 2,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Evidence of pathological diagnosis of primary tumor;
2. Brain metastases confirmed by enhanced magnetic resonance imaging;
3. Complete clinical information

Exclusion criteria

1. Survival time less than 30 days;
2. If surgical treatment is accepted, the surgical treatment is not tumor resection, but ventricle puncture, biopsy and other non-tumor reducing surgery;
3. Incomplete clinical data;
4. Patients with 2 or more types of tumors.

Trial design

2,000 participants in 6 patient groups

local treatment group vs non-local treatment group

Description:

Participants underwent local treatments such as surgical resection or radiotherapy or surgical resection plus radiotherapy were divided into local treatment group or otherwise into non-local treatment group

Treatment:

Procedure: neurosurgical resection

systemic treatment group vs non-systemic treatment group

Description:

Participants underwent systemic treatments such as chemotherapy or target therapy or chemotherapy plus target therapy were divided into systemic treatment group or otherwise into non-systemic treatment group

local treatment group vs systemic treatment group

Description:

Participants underwent local treatments such as surgical resection or radiotherapy or surgical resection plus radiotherapy were divided into local treatment group; Participants underwent systemic treatments such as chemotherapy or target therapy or chemotherapy plus target therapy were divided into systemic treatment group

Treatment:

Procedure: neurosurgical resection

local treatment group vs local treatment+systemic treatment group

Description:

Participants underwent local treatments such as surgical resection or radiotherapy or surgical resection plus radiotherapy were divided into local treatment group; Participants underwent local treatment plus systemic treatment were divided into local treatment+systemic treatment group

Treatment:

Procedure: neurosurgical resection

systemic treatment group vs local treatment+systemic treatment group

Description:

Participants underwent systemic treatments such as chemotherapy or target therapy or chemotherapy plus target therapy were divided into systemic treatment group; Participants underwent local treatment plus systemic treatment were divided into local treatment+systemic treatment group

Treatment:

Procedure: neurosurgical resection

local treatment+systemic treatment group vs non-local treatment+systemic treatment group

Description:

Participants underwent local treatment plus systemic treatment were divided into local treatment+systemic treatment group or otherwise into non-local treatment+systemic treatment group

Treatment:

Procedure: neurosurgical resection