TRENDY Follow-up: Study on Endothelial Function in Subjects With Type 2 Diabetes Mellitus

University of Erlangen-Nürnberg Medical School

Status: Completed

Conditions: Type 2 Diabetes Mellitus

Treatments: Drug: Telmisartan 80 mg/d; Drug: Ramipril 10 mg/d

Study type: Observational

Funder types: Other

Identifiers

NCT00905528

Re.-No. 3204

SFB TP B5

Details and patient eligibility

About

Basal nitric oxide (NO) activity plays a pivotal role in the regulation of glomerular hemodynamics, and in animal experiments its alteration has been associated with morphological changes characteristic of diabetic nephropathy. The investigators aimed to assess in a prospective study: 1. basal NO activity of renal vasculature and 2. renal hemodynamics to examine whether impairment of basal NO activity of the renal vasculature is related to development and progression of diabetic nephropathy and other cardiovascular endpoints.

Enrollment: 69 estimated patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 Diabetes mellitus

Exclusion criteria

• Macroalbuminuria
• Symptomatic cardiovascular disease

Trial design

69 participants in 2 patient groups

A

Description:

Subjects with type 2 diabetes mellitus, eGFR \> 80, hypertension, no overt proteinuria

Treatment:

Drug: Telmisartan 80 mg/d

B

Description:

Subjects with type 2 diabetes mellitus, eGFR \> 80, hypertension, no overt proteinuria

Treatment:

Drug: Ramipril 10 mg/d