Trial Comparing hCG Triggering Versus GnRH Agonist Triggering in PCOS Patients

AZ Jan Palfijn Gent

Status and phase: Completed; Phase 4

Conditions: PCOS; Infertility

Treatments: Drug: GnRh agonist +1500E hCG

Study type: Interventional

Funder types: Other

Identifiers

NCT01683513

Dr. Decleer W

Details and patient eligibility

About

In this study the investigators compare the traditional way of triggering with a new way in patients with Poly Cystic Ovary Syndrome (PCOS). This to reduce the risque of Ovary Hyper Stimulation Syndrome (OHSS) in In Vitro Fertilization/ IntraCytoplastic Sperm Injection (IVF/ ICSI) treatment. The investigators also compare the number of mature oocytes, embryo's and pregnancy rate.

Enrollment: 120 patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ICSI patients below 38 years
• 1, 2 and 3e IVF cycle
• Body Mass Index (BMI) less than 32
• PCOS patients

Exclusion criteria

• endocrinal diseases or problems

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

humaan chorion gonadotropine

No Intervention group

Description:

ovulation induction with 5000E hCG

GnRH agonist + 1500E hCG

Active Comparator group

Description:

ovulation induction with GnRH agonist and 1500E hCG one hour after egg retrieval

Treatment:

Drug: GnRh agonist +1500E hCG