Trial Comparing hCG Triggering Versus hCG Associated With GnRH Agonist

AZ Jan Palfijn Gent

Status and phase: Completed; Phase 4

Conditions: Infertility

Treatments: Drug: Decapeptyl Daily; Drug: pregnyl

Study type: Interventional

Funder types: Other

Identifiers

NCT01607203

Dr. Decleer Wim

Details and patient eligibility

About

The purpose of this study is to see whether patients triggered with only human Chorion Gonadotropin (hCG) have higher number of Metaphase II oocytes (MII) and implantation rate than patients triggered with hCG combined with Gonadotropin Releasing Hormone (GnRH) agonist.

Enrollment: 120 patients

Sex: Female

Ages: Under 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Intra-cytoplasmic sperm injection (ICSI) patients below 38 years
• 1,2 or 3 rd IVF-cycle

Exclusion criteria

• polycystic ovary syndrome (PCOS) patients
• patients with endocrinological diseases or problems

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

hCG

Active Comparator group

Description:

5000 IU Pregnyl SC

Treatment:

Drug: pregnyl

hCG and GnRH agonist

Active Comparator group

Description:

5000 IU Pregnyl SC + 0.2 mg Decapeptyl daily SC

Treatment:

Drug: pregnyl

Drug: Decapeptyl Daily