Trial Comparing Two Techniques of Celiac Plexus Neurolysis for Treatment of Pain in Carcinoma Pancreas

Asian Institute of Gastroenterology, India

Status and phase: Unknown; Phase 1

Conditions: Pancreatic Cancer

Treatments: Procedure: percutaneous fluoro guided celiac plexus neurolysis; Procedure: EUS guided neurolysis

Study type: Interventional

Funder types: Other

Identifiers

NCT01182831

AIG-GIA-201001

Details and patient eligibility

About

Coeliac plexus neurolysis (CPN) is a management option for pain control in carcinoma pancreas.CPN is conventionally performed by percutaneous technique with fluoroscopic guidance. Endoscopic ultrasound (EUS) is increasingly used for CPN as it offers a better visualization of the plexus. There are limited data comparing the two modalities.The patients are on follow-up for 6 months post neurolysis.

Full description

Carcinoma pancreas patients with abdominal pain requiring daily analgesics for more than 4 weeks were included.we are randomising about 100 patients into two groups to undergo either of the two procedures, i.e. celiac plexus neurolysis by percutaneous technique or by endoscopic ultrasound guided technique.The pain scores have been recorded by visual analogue scale for an average follow-up of 6 months.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all patients with carcinoma pancreas

Exclusion criteria

• patients below 18 years of age and who have not given consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

percutaneous fluoro guided celiac plexus neurolysis

Active Comparator group

Treatment:

Procedure: percutaneous fluoro guided celiac plexus neurolysis

EUS guided neurolysis

Active Comparator group

Treatment:

Procedure: EUS guided neurolysis