Trial of AB-110 in Adults With Hematologic Malignancies Undergoing Cord Blood Transplantation

Angiocrine Bioscience

Status and phase

Completed

Phase 1

Conditions

Acute Lymphoblastic Leukemia in Remission

Myelodysplastic Syndromes

Other Acute Leukemias

Acute Myeloid Leukemia

Treatments

Biological: Unmanipulated Umbilical Cord Blood (UCB)

Biological: AB-110

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT03483324

AB-110-001

Details and patient eligibility

About

A phase 1b, open label, multi-center trial of AB-110 in adults with hematologic malignancies, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and myelodysplasia (MDS) undergoing cord blood transplantation. Subjects will receive unmanipulated cord blood (UCB) and AB-110 expanded CD34 enriched hematopoietic progenitor cells (HSPC).

Enrollment

10 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients must have received some immunosuppressive chemotherapy in the preceding 3 months.
Acute myelogenous leukemia (AML):
1. Complete first remission (CR1) at high risk for relapse
2. Complete second remission (CR2).
3. No documented myelofibrosis at screening marrow biopsy
Acute lymphoblastic leukemia (ALL):
1. Complete first remission (CR1) at high risk for relapse
2. Complete second remission (CR2).
Other acute leukemias that are of ambiguous lineage or of other types
Any acute leukemia with marrow aplasia or without adequate count recovery.
Myelodysplastic Syndrome (MDS)
Karnofsky score > 70 %.
Calculated creatinine clearance > 60 ml/min.
Bilirubin < 1.5 mg/dL, ALT < 3 x upper limit of normal
Pulmonary function (FVC, FEV1 and corrected DLCO) > 50% predicted.
Left ventricular ejection fraction > 50%.
Albumin > 3.0 g/dL.
Negative antiviral serology:
Negative human immunodeficiency virus (HIV) antibody.
Negative human T-lymphotropic virus (HTLV)-1 and 2 antibodies.
Negative hepatitis B surface antigen (HBsAg) and undetectable hepatitis B virus (HBV) DNA
Negative hepatitis C virus (HCV) antibody or negative HCV ribonucleic acid (RNA)
For female subjects of childbearing potential:
1. A negative serum pregnancy test
2. Willing to use contraception throughout the study period.
Male subjects must be willing to use a recommended method of contraception throughout the study period, and to refrain from sperm donation throughout the study period.
Two appropriate CB units identified for the subject.
In the judgment of the investigator, participation in the protocol offers an acceptable benefit-to-risk ratio when considering current disease status, medical condition, and the potential benefits and risks of alternative treatments for the subject's cancer.
Willingness and ability to comply with scheduled visits, drug administration plan, protocol-specified laboratory tests, other study procedures, and study restrictions.
Evidence of a signed informed written consent

Exclusion criteria

Pregnancy or breastfeeding.
Current active, uncontrolled bacterial, viral, or fungal infection
Prior allogeneic or autologous HCT at any time.
Active malignancy other than the one for which AB-110 transplant is being performed within 12 months of enrollment.
Any identified and available 10/10 HLA-matched related donor or 10/10 HLA-matched unrelated donor.
Have evidence of recipient donor specific anti-HLA antibodies.
Active central nervous system (CNS) disease at time of screening.
Documented allergy to DMSO, mouse or bovine proteins, or iron.
Subject has other conditions that in the opinion of the investigator would place the subject at increased risk for toxicity by participation in the study.
Psychiatric condition making the patient unlikely to comply with protocol therapy, required tests and follow-up.