Trial of Aerobic Exercise in Patients Undergoing Outpatient Hemodialysis

University of Manitoba

Status

Completed

Conditions

Kidney Failure, Chronic

Treatments

Behavioral: ergometer exercise during hemodialysis

Behavioral: pedometer activity outside of hemodialysis

Study type

Interventional

Funder types

Other

Identifiers

NCT00492362

B2007:067

Details and patient eligibility

About

Randomized controlled trial comparing effects of ergometer exercise during hemodialysis to effects of pedometer use outside of hemodialysis on exercise capacity, functional status, quality of life and adequacy of hemodialysis.

Full description

Study Design:

Prospective, randomized, controlled trial of chronic hemodialysis outpatients within the Manitoba Renal Program.

Potential patients include any individual receiving chronic outpatient hemodialysis in Winnipeg (Seven Oaks, Sherbrook, Central and St. Boniface dialysis units) and the Brandon hemodialysis unit.

Exercise Interventions:

Patients will be block randomized to one of the following 2 interventions:

Group A: Cycling on an ergometer GOAL 60 minutes 3 times per week on hemodialysis for 24 weeks A cycling ergometer will be placed on the floor in front of the patient's dialysis chair or at the foot of the bed (if there are only beds available in that unit). The patient will be allowed to exercise anytime during the first half of each dialysis treatment. Goal frequency will be 3 times per week during their usual scheduled hemodialysis treatments.

Group B: Pedometers This group will each receive a pedometer (StepsCount®) at the onset of the study following exercise testing. They will be educated regarding the technical use of the pedometer and will receive the handout entitled "Pedometer Information Sheet: Get Physically Active One Step at a Time!" They will also receive verbal education regarding use of the pedometer and goal activity levels from the exercise study supervisor.

Enrollment

60 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All adult (>18 years old) patients
Treated with hemodialysis for > 3 months
Hemoglobin > 100 g/L over the previous 2 months
Kt/V > 1.2 for last month and no history of shortened dialysis due to hemodialysis access issues or frequent alarming during dialysis due to poor access will be eligible for the study.
Study patients must also be likely able to complete 12 consecutive weeks of exercise (i.e. no travel, change of modality, elective surgery planned) and must be able to comprehend instructions in English.

Exclusion criteria

Acute medical illness in last month
Unstable hemodialysis with frequent hypotension over the past month
Active cardiovascular disease (stroke or acute coronary syndrome, unstable angina) in last 3 months
Lower extremity amputation with no prosthesis (inability to pedal a bike)
Spine compression fractures
Severe musculoskeletal pain at rest or with minimal activity
Inability to sit, stand or walk unassisted (walking devices such as cane will be allowed)
Shortness of breath at rest or with activities of daily living (NYHA Class IV)
Labile glycemic control with hypoglycaemic episodes > 1x/week.