Trial of Autologous Mesenchymal Stem Cells in Patients With Multiple System Atrophy

Yonsei University

Status and phase: Completed; Phase 2

Conditions: Multiple System Atrophy

Treatments: Biological: normal saline; Biological: autologous mesenchymal stem cells

Study type: Interventional

Funder types: Other

Identifiers

NCT00911365

4-2008-0137

Details and patient eligibility

About

This study is based on positive results in open label trial of mesenchymal stem cells therapy in patients with Multiple System Atrophy (MSA).

Enrollment: 27 patients

Sex: All

Ages: Under 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 75 Years Old or Less
• Multiple System Atrophy
• Voluntary Participants

Exclusion criteria

• Doubted dementia (MMSE < 24)
• Severe febrile condition
• Serum SGOT/SGPT three times above
• Malignant mass

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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27 participants in 2 patient groups, including a placebo group

normal saline

Placebo Comparator group

Treatment:

Biological: normal saline

autologous mesenchymal stem cells

Experimental group

Treatment:

Biological: autologous mesenchymal stem cells