Trial of Endobronchial Ultrasound Guided Fine Needle Aspiration Techniques

American University of Beirut Medical Center

Status: Completed

Conditions: Lung Cancer

Treatments: Device: EBUS guided FNA with and without suction

Study type: Interventional

Funder types: Other

Identifiers

NCT01741571

AmericanUBMC

Details and patient eligibility

About

Endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TBNA) techniques have not been well studied. The investigators will conduct a randomized study comparing the diagnostic yield and specimen quality of EBUS-FNA performed with and without suction applied.

Full description

Consecutive patients with suspected malignant peribronchial masses or lymph nodes undergoing endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) will be enrolled. All participants will have 4 needle aspirations of each targeted peribronchial lesion. Two needle aspirations will be performed while applying suction and 2 needle aspirations will be performed without applying suction in random order. The investigators will compare the diagnostic yield and the quality of the specimens obtained using the two techniques.

Enrollment: 32 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult undergoing EBUS at AUBMC for suspected malignancy

Exclusion criteria

• Coagulopathy
• The lesion cannot be sampled because of intervening tumor or blood vessels.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Single Blind

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32 participants in 2 patient groups

EBUS guided FNA with suction

Active Comparator group

Description:

Device/procedure: lymph node tissue collection using fine needle aspiration with suction applied. Four fine needle aspirations will be taken sequentially from each lymph node. Two with suction and two without suction applied.

Treatment:

Device: EBUS guided FNA with and without suction

EBUS guided FNA without suction

Experimental group

Description:

Device/procedure: lymph node tissue collection using fine needle aspiration without suction applied. Four fine needle aspirations will be taken sequentially from each lymph node. Two with suction and two without suction applied.

Treatment:

Device: EBUS guided FNA with and without suction