Trial of Endometrial Scratch Prior to Frozen Embryo Transfer in Patients With Recurrent Implantation Failure

Brown Fertility

Status: Withdrawn

Conditions: Recurrent Implantation Failure in Setting of Artifically Prepared Endometrium

Treatments: Procedure: endometrial biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT03157765

EMB for RIP/FET

Details and patient eligibility

About

Patients with a history of recurrent implantation failure who are planning a frozen embryo transfer (FET) are enrolled into the program. Patients are randomized to an endometrial biopsy prior to starting estrogen to prepare for the transfer of warmed vitrified embryos or to routine care.

Full description

Patients who failed to achieve a clinical pregnancy after embryo transfer of at least three high quality embryos in at least two IVF or FET cycles and for whom their last failed cycle was a frozen embryo transfer are offered the opportunity to enroll in this study. All patients will follow our routine FET protocol.

On a randomized basis, selected patients will undergo an endometrial biopsy using a Pipelle disposable device in the week prior to starting estrogen to prepare her endometrium.

Sex: Female

Ages: 18 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• At least two prior consecutive failed IVF or FET cycles with transfer of at least 3 high quality embryos and with last cycle a FET cycle

Exclusion criteria

• Alternate explanation for implantation failure (e.g., intrauterine pathology)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

EMB intervention

Experimental group

Description:

These patients receive and endometrial biopsy

Treatment:

Procedure: endometrial biopsy

Routine care

No Intervention group

Description:

These patient receive routine care