Trial of Oxytocin Alone Versus Oxytocin and Propranolol for the Treatment of Abnormal Labor

University of California Irvine (UCI)

Status and phase: Withdrawn; Phase 2

Conditions: Dysfunctional Labor

Treatments: Other: IV Placebo; Drug: Propranolol

Study type: Interventional

Funder types: Other

Identifiers

NCT00315913

HS #2004-3997

Details and patient eligibility

About

The purpose of this study is to determine whether propranolol is better than oxytocin for the treatment of labor abnormalities. The endpoint is the rate of vaginal delivery experienced by women receiving prolonged oxytocin versus propranolol.

Full description

This trial was designed to test if propranolo can reduce the c section rate for dysfuctional labor. Due to stringent inclution and exclusion criteria and low enrollment the study was closed.

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Must be term pregnancy (> 37 weeks)
• Vertex presentation
• Active labor (4-5 centimeters dilated)

Exclusion criteria

• Heart disease
• Diabetes
• Currently taking propranolol
• Contraindications to labor or vaginal delivery
• Multiple gestations
• Preterm
• Chorioamnionitis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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0 participants in 2 patient groups, including a placebo group

IV Propranolol

Experimental group

Description:

IV dose propranolol

Treatment:

Drug: Propranolol

IV Placebo

Placebo Comparator group

Description:

IV Placebo of saline solution equal to propranolol in volume

Treatment:

Other: IV Placebo