Trial of Pemetrexed in Combined With Cisplatin for the Treatment of Advanced Breast Cancer

Chinese Academy of Medical Sciences & Peking Union Medical College

Status and phase: Completed; Phase 4

Conditions: Locally Advanced Malignant Neoplasm

Treatments: Drug: pemetrexed plus cisplatin

Study type: Interventional

Funder types: Other

Identifiers

NCT01143974

CH-BC-008

Details and patient eligibility

About

For patients resistant to enthrycycline and taxanes, there is no standard regimen. Pemetrexed alone had certain efficacy in treatment of advance breast cancer. Platin was also a effective drug for advanced breast cancer. The combination of these two drug may have a synergy with each other in treatment of advanced breast cancer.

Full description

combination of pemetrexed and cisplatin to treat advanced breast cancer. Previous regimen no more than 3 which including enthrycycline and taxanes(paclitaxel and/or docetaxel)

Enrollment: 28 patients

Sex: Female

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-70 years old
• Resistant to enthracycle and taxanes
• Has measurable disease

Exclusion criteria

• Has more than 3 previous chemotherapy regimens

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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28 participants in 1 patient group

PC Regimen

Experimental group

Treatment:

Drug: pemetrexed plus cisplatin