Trial of Safe Water Storage Among People Living With HIV

London School of Hygiene and Tropical Medicine

Status

Unknown

Conditions

Waterborne Disease

Diarrhea

HIV

Treatments

Device: Safe storage device

Study type

Interventional

Funder types

Other

Identifiers

NCT01376336

QA308

Details and patient eligibility

About

Environmental health-related pathogens include faecal-oral, diarrhoeagenic microbes that may be transmitted via drinking water and are related to sanitation and hygiene. Previous research has suggested that safeguarding household drinking water against recontamination may be a critical intervention that can reduce risks of diarrheal diseases and may be especially important for people living with HIV/AIDS (PLWHA) and other vulnerable populations (Clasen et al. 2007). The investigators propose here a randomised, controlled trial of a household safe storage container for drinking water in a well defined, HIV-impacted population in peri-urban Lusaka, Zambia. After a baseline data collection period (9 months) half of all households (150 households) will be given a safe water storage container specifically designed to prevent recontamination of water in household use. All households will be followed for an additional 9 months. Results of this study will help determine whether this promising water quality intervention can reduce diarrhoea and related outcomes in this and similar vulnerable populations.

Full description

Specific Aim #1: To assess environmental health-related risk and outcomes in a low income peri-urban area of Zambia with a high percentage of people living with HIV/AIDS (PLWHA) (longitudinal observational cohort study and baseline) (Year 1). We will assemble a rich dataset on environmental health-related risk factors in a well defined population, with a focus on household drinking water quality and other water, sanitation, and hygiene (WSH) exposures.

Specific Aim #2: To quantify the WSH-related disease burden among PLWHA, compared with those without HIV/AIDS (individual and household level stratification) (conclusion of baseline). After nine months of data collection, we will perform an initial analysis to determine WSH-related risk by HIV status.

Specific Aim #3: To assess the impact of a water quality intervention on the longitudinal prevalence of Highly Credible Gastrointestinal Illness (HCGI) among PLWHA (randomized controlled trial, year 2). We will conduct a randomised, controlled trial of a safe water storage intervention. We will assess the health impacts of this intervention, with particular focus on the high-risk groups of PLWHA and children under 5 years of age.

Enrollment

1,600 estimated patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Resident of Misisi compound, Lusaka
Willing to participate in the study
Is able to give informed consent and does so
Household has one or more children who are aged 48 months or less at the start of the trial
The household stores drinking water in the home

Exclusion criteria

Not a resident of Misisi compound, Lusaka
Unwilling to participate in the study
Unable to give informed consent or chooses not to participate
Household does not have one or more children aged 48 months or less at the start of the trial
The household does not store drinking water in the home