Trial of the Use of Doxycycline After Rotator Cuff Repair

Penn State Health

Status: Withdrawn

Conditions: Rotator Cuff Injury

Treatments: Drug: Doxycycline; Drug: sugar pill

Study type: Interventional

Funder types: Other

Identifiers

NCT02388477

STUDY00002143

Details and patient eligibility

About

The purpose of this study is to examine healing after rotator cuff repair in subjects either treated with Doxycycline or placebo post-operatively.

Full description

Basic Science small animal model data indicates that matrix metalloproteinase (MMP) inhibition via doxycycline results in improved early rotator cuff repair biomechanics and histology. Rotator cuff repair failure and retear is a significant clinical problem. The effects of MMP inhibition on human rotator cuff tear repair healing and outcomes is unknown, but may potentially improve healing rates and outcomes. Our purpose is to evaluate the effects of early oral doxycycline on healing and outcomes following arthroscopic rotator cuff repair.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• repair of rotator cuff
• age 18 and above
• able to swallow capsules

Exclusion criteria

• less than 18
• unable to read or understand consent form
• unable to swallow capsules
• allergy to doxycycline

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 2 patient groups, including a placebo group

Doxycycline

Active Comparator group

Description:

oral doxycycline, 2 weeks, twice a day,

Treatment:

Drug: Doxycycline

sugar pill

Placebo Comparator group

Description:

sugar pill, same size, shape, and color as comparator, twice a day for 2 weeks.

Treatment:

Drug: sugar pill