Trial of Unicompartmental Versus Total Knee Arthroplasty

Anderson Orthopaedic Research Institute

Status: Active, not recruiting

Conditions: Osteo Arthritis Knee

Treatments: Procedure: Unicompartmental knee arthroplasty; Procedure: Total knee arthroplasty

Study type: Interventional

Funder types: Other

Identifiers

NCT03385759

17-2931

Details and patient eligibility

About

This study is a prospective, randomized trial to compare patient outcomes of unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) for the treatment of medial compartment osteoarthritis.

Enrollment: 112 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• medial compartment osteoarthritis of the knee
• knee flexion greater than greater than 90 degrees
• flexion contracture of less than 10 degrees
• varus deformity < 20 degrees
• grade IV degeneration of the medial compartment

Exclusion criteria

• lateral compartment degenerative changes
• previous lateral meniscectomy
• anterior cruciate ligament deficiency
• body mass index > 40
• inflammatory arthritis
• history of septic arthritis
• hemoglobin A1c > 8.0
• chronic liver disease
• stage 3A or greater chronic renal disease
• active IV drug abuse
• patients requiring thromboembolic prophylaxis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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112 participants in 2 patient groups

UKA

Active Comparator group

Description:

Medial unicompartmental knee arthroplasty

Treatment:

Procedure: Unicompartmental knee arthroplasty

TKA

Active Comparator group

Description:

Total knee arthroplasty

Treatment:

Procedure: Total knee arthroplasty