Trial of Vaccine Therapy in Recurrent Platinum Sensitive Ovarian Cancer Patients

Steinar Aamdal

Status and phase

Terminated

Phase 2

Phase 1

Conditions

Recurrent Epithelial Ovarian Cancer

Treatments

Biological: DC-006 vaccine

Study type

Interventional

Funder types

Other

Identifiers

NCT01334047

DC-006

Details and patient eligibility

About

In this study the investigators will include patients with relapsed epithelial ovarian cancer. In spite of increased rates of complete response to initial chemotherapy, most patients with advanced ovarian cancer relapse and succumb to progressive disease. Immunotherapy may have potential for consolidation therapy. Dendritic cell vaccine is well toleranted in previous studies, with minor side effects and no serious adverse events registrated In this study, patients will receive DC-vaccine therapy after response to platinum treatment at relapse. The investigtors include patients in good clinical condition with no severe symptoms of the disease. If patients relapse during vaccine treatment, they will be discontinued from the study.

The investigators have included hTERT- and survivin mRNA in addition to amplified cancer stem cell mRNA in the vaccine.

Full description

Study Period:

Estimated date of first patient enrolled: First quarter of 2011
Anticipated recruitment period: 3 years
Estimated date of last patient completed: First quarter of 2017, follow up to 2022.

Treatment duration:

Patients will receive intradermal immunization once a week for 4 weeks followed by monthly "vaccine boost" during the first year. Patients that show immunological response will continue with vaccination every month the second and third year or as long as there is vaccine available. The patients will have follow up for 5 years or until progression of disease as evaluated by the investigator.

Enrollment

5 patients

Sex

Female

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically confirmed epithelial ovarian cancer. Histologic documentation of the original primary tumor is required via pathology report.
Completed first line treatment (surgery and adjuvant or neoadjuvant treatment with carboplatine and paclitaxel)
Relapsed and platinum sensitive epithelial ovarian carcinoma patients with response to chemotherapy in recurrent disease
If surgery is indicated, the patient should be surgically treated and then starts vaccination with a minimum interval of 28 days.
Must be ambulatory with an ECOG performance status 0 or 1.
Life expectancy ≥ 6 months
Must be of 18-75 years of age
Must have lab values as the following:
- ANC ≥ 1.5 x 109/L
- Platelets ≥ 100 x 109/L
- Hb ≥ 9 g/dL (≥ 5.6 mmol/L)
- Creatinine ≤ 140 μmol/L (1.6 mg/dL); if borderline, the creatinine clearance ≥ 40 mL/min
- Bilirubin within the upper limit of normal
- ASAT and ALAT ≤ 2.5 the upper limit of normal
- Albumin levels above lower normal value
If the patient has preserved fertility after primary treatment, she must practice adequate contraception during the study treatment
Signed informed consent and expected cooperation of the patients for the treatment and follow up must be obtained and documented according to ICH/GCP, and national/local regulations.

Exclusion criteria

Eligible to otherwise curative treatment.
History of prior malignancy, other than ovarian cancer, within the last 5 years, with the exception of curatively treated basal cell carcinoma and cancer in situ cervix uteri.
Prior surgery within the past 28 days
Clinical ascites or metastatic pleural fluid
Active infection requiring antibiotic therapy.
Have known active central nervous system (CNS) or leptomeningeal metastasis (brain metastasis). Patients with signs or symptoms of neurological compromise should have appropriate radiographic imaging performed before study entry to rule out brain metastasis.
Significant cardiac or other medical or mental illness that would limit activity or survival, such as severe congestive heart failure, unstable angina, serious cardiac arrhythmia or psychosis.
Pregnancy or lactation
Previous adverse reactions to vaccines such as asthma, anaphylaxis or other serious reactions.
History of immunodeficiency or autoimmune disease such as but not limited to rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis-dermatomyositis, juvenile onset insulin dependent diabetes, or a vasculitic syndrome.
Positive for syphilis (treponema pallidum), HIV, Hepatitis B and C tests
Use of systemic glucocorticoids.
Prior anti-cancer treatment, including radiotherapy, chemotherapy immunotherapy and/or immunomodulating agents stopped for less than 4 weeks before first study treatment administration. Anti hormonal treatment, such as Tamoxifen, may continue until first study treatment administration.
Any reason why, in the opinion of the investigator, the patient should not participate.