Trial of Vitamin C as Add on Therapy for Children With Idiopathic Epilepsy

Ain Shams University

Status and phase: Unknown; Phase 2

Conditions: Idiopathic Epilepsy

Treatments: Dietary Supplement: Vitamin C

Study type: Interventional

Funder types: Other

Identifiers

NCT02369822

Vitamin C, Children, Epilepsy

Details and patient eligibility

About

There are no solid treatment guidelines for idiopathic intractable epilepsy in children. The investigators propose that vitamin C being an antioxidant will improve seizure frequency and EEG in children with idiopathic intractable epilepsy.

Full description

Is vitamin C; being an antioxidant based on the hypothesis of oxidative stress as a provocation factor for idiopathic epilepsy low in those with idiopathic epilepsy, and is it lower in those with refractory than those with newly diagnosed? Will vitamin C supplementation for 1 month be efficient to raise the vitamin C level and will it improve seizures and EEG findings in those with idiopathic epilepsy?

Enrollment: 60 estimated patients

Sex: All

Ages: 2 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Normal neuroimaging

Exclusion criteria

• Developmental delay.
• Suspected metabolic problems.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Vitamin C supplemented

Experimental group

Description:

patients with refractory idiopathic epilepsy will receive vitamin C supplement according to age for 1 month

Treatment:

Dietary Supplement: Vitamin C

None supplemented

No Intervention group

Description:

followed up for 1 month