Trigeminal Brainstem Mapping

Universitätsklinikum Hamburg-Eppendorf

Status: Completed

Conditions: Migraine; Headache Disorders, Primary

Treatments: Device: Electric Current Stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03999060

TrigeminalBrainstemMapping

Details and patient eligibility

About

To what extent the somatotopy of the 3 branches of the trigeminal nerve (V1,V2,V3) as well as the greater occipital nerve (GON) in the brainstem but also in the thalamus and the insula can be mapped using functional imaging and BOLD in humans is not known but might play an important role in imaging headache diseases. The aim is to map their somatotopy by random stimulation of V1, V2, V3 and the GON with painful electrical input during acquisition of BOLD-fMRI.

Enrollment: 36 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy
• suitable fo MRI

Exclusion criteria

• headache disease
• psychological disorder
• pregnancy
• all exclusion criteria necessary for imaging in a 3 T MRI scanner

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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36 participants in 1 patient group

Electric Stimulation

Experimental group

Treatment:

Device: Electric Current Stimulation