Trigeminal Brainstem Mapping 2: Higher Cortical Strucureas As Well As Subnuclei of the Spinal Trigeminal Nucleus

Universitätsklinikum Hamburg-Eppendorf

Status: Enrolling

Conditions: Migraine Disorders

Treatments: Device: Electric Current Stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT06535880

TrigeminalBrainstemMapping2

Details and patient eligibility

About

In previous studies clustering of the three branches of the trigeminal nerve in brainstem were shown, cerebellum and periaqueductal gray. To further evaluate higher cortical structures, which were not covered by our previous field of view (FOV) and to further investigate the identified 'subnuclei' of the spinal trigeminal nucleus, here the aim is to scan the whole brain as well as the brainstem and the upper spinal cord during trigeminal nociceptive as well as non-nociceptive electrical stimulation of all three branches of the trigeminal nerve (and the arm as a somatic control site) during acquisition of BOLD-fMRI in humans.

Full description

Preprocessing and processing of the MR data will follow our previous publications (Mehnert et al 2023, Mehnert et al 2024)

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy
• suitable fo MRI

Exclusion criteria

• headache disease
• psychological disorder
• pregnancy
• all exclusion criteria necessary for imaging in a 3 T MRI scanner

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

Electric Stimulation

Experimental group

Description:

Electric stimulation with a Digitimer DS7AH HV Current Stimulator delivered with 4 shielded electrodes mounted on the participants head and arm.

Treatment:

Device: Electric Current Stimulation