Triglyceride-Glucose Indices and Left Ventricular Speckle Tracking in Predicting Coronary Artery Disease Severity

Damanhour University

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Diagnostic Test: TyG-derived index.; Diagnostic Test: Left Ventricular Speckle Tracking

Study type: Observational

Funder types: Other

Identifiers

NCT07063628

Predicting CAD Severity

Details and patient eligibility

About

Our study specifically will address the value of modified triglyceride glucose indices versus left ventricular speckle tracking in prediction of severity of coronary artery disease assessed by Gensini score.

Full description

A cross sectional study that will be conducted in Cardiovascular Department of Tanta University in Egypt in the period from May to July 2025 . Two hundred patients diagnosed with coronary artery diseases were included in the study. Patients were considered to have confirmed coronary artery disease through angiographically proven CAD.

Provision of privacy:

Privacy of all data is guaranteed and there will be a code number for every patient and include all of his or her investigations.

Informed consent:

Informed written consent will be obtained from all patients after full explanation of benefits and risks of the study.

Methods: Study patients and procedures:

Selection criteria included any patient with chronic stable angina and proved coronary artery disease by coronary angiography Exclusion criteria included: Any patients with acute coronary syndrome, arrhythmias, previous Percutaneous coronary intervention (PCI) or Coronary Artery Bypass Graft (CABG) surgery

All the participants were subjected to following:

1. History taking for presence of risk factors of cardio vascular disease as age, sex, smoking, physical inactivity, diabetes and hypertension.

2. Physical examination including height, weight and waste circumference

3. Resing 12 leads ECG

4. Laboratory investigations:

   • Fasting blood glucose (FBG)
   • Triglyceride (TG), TG index.
   • Total Cholesterol level
   • Renal Function test . Echocardiographic evaluation

5. Coronary angiography 7. Gensini score calculated by summation of the individual coronary segment scores.

Enrollment: 508 patients

Sex: All

Ages: 38 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of CAD with ≥50% stenosis in at least one major coronary artery.

Exclusion criteria

• Patients with acute coronary syndrome, arrhythmias, previous coronary interventions (PCI or CABG), or inability to undergo echocardiographic assessment.